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More evidence that increased stiffness of the large arteries (as occurs in old age) can lead to poor outcomes for the blood vessels in the brain:


Atherosclerosis is more likely to develop in locations where blood flow is disturbed, like artery branches or curves. We find that a Western Diet, high in fat and sucrose, increases the atherosclerosis response to disturbed blood flow. However, contrary to our hypothesis, aging did not change the response:


Telomeres, the ends of chromosomes, form a protective loop called a “cap.” We provide cause-and-effect evidence that removing this cap leads to artery dysfunction, similar to aging:


We find that increasing angiogenesis and/or altering vascular stability protects against metabolic dysfunction with a high fat diet:


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