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More evidence that increased stiffness of the large arteries (as occurs in old age) can lead to poor outcomes for the blood vessels in the brain: https://physoc.onlinelibrary.wiley.com/doi/10.1113/EP087453

 

Atherosclerosis is more likely to develop in locations where blood flow is disturbed, like artery branches or curves. We find that a Western Diet, high in fat and sucrose, increases the atherosclerosis response to disturbed blood flow. However, contrary to our hypothesis, aging did not change the response: https://rdcu.be/boDWR

 

Telomeres, the ends of chromosomes, form a protective loop called a “cap.” We provide cause-and-effect evidence that removing this cap leads to artery dysfunction, similar to aging: https://www.sciencedirect.com/science/article/pii/S002228281830751X

 

We find that increasing angiogenesis and/or altering vascular stability protects against metabolic dysfunction with a high fat diet: https://onlinelibrary.wiley.com/doi/abs/10.1111/micc.12540

 

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